Fig. 3.

PBPK absorption model for inhaled drugs (Additional Dosage Routes Module implemented in the GastroPlus™ software). Yellow arrows, drug input to the lung compartments; light green boxes, lung compartments; dark green box, GI tract compartment (stomach, Advanced Compartmental Absorption and Transit model); blue boxes, systemic disposition compartments; black arrows, transport processes to/from the lung; blue arrows, systemic distribution processes, adapted and modified with permission from (48)