Fig. 5.

Model for an IFN-α ceRNA network against miR-1270. Following SeV infection, specific subsets of IFN-α AS RNAs (-α1, -α7, -α8, -α10 and -α14) as well as IFN-α mRNAs (-α8, -α10, -α14 and -α17), which share MRE-1270s, form a ceRNA network to titrate away miR-1270 from IFN-α1 mRNA, allowing for its expression. Several cellular mRNAs, including CAPRIN1 mRNA, which share MRE-1270s, also participated in the network. Furthermore, upon recognition of the IFN-α1 mRNA/BSL region, IFN-α1 AS increases the stability of the mRNA [11]