Fig. 6.

Thrombolytic efficacy data for rt-PA, rt-PA and Definity, and t-ELIP at equivalent enzymatic activity of rt-PA, with and without intermittent 120-kHz ultrasound exposure (US). a Maximum lytic rate for all treatment arms determined using Eq. (3 ), with p values indicated in Table 4. b Time to 50 % clot width reduction, determined from Eq. (2), with p values indicated in Table 5. c Fractional clot loss at the completion of the treatment (30 min), using Eq. (1), with p values indicated in Table 6. None of the treatments are statistically different than the all of the other treatment arms for each rt-PA concentration and thrombolytic metric shown in a, b, and c. The lipid concentration of t-ELIP is indicated on the top abscissa label. The sample size for each treatment (n) is 12