Table 3.
Treatment characteristics for patients treated with standard RT or esophagus and contralateral lung-sparing IMRT.
| Normal tissue-sparing IMRT (n = 44) | Standard (n = 38) | p | |
|---|---|---|---|
| Radiation dose | |||
| Median | 66 | 63 | 0.04 |
| <59.4 Gy | 6 (14%) | 9 (24%) | |
| 59.4–63 Gy | 11 (25%) | 16 (32%) | |
| 63.1–66 Gy | 11 (25%) | 5 (13%) | |
| >66.1 Gy | 16 (36%) | 8 (21%) | |
| Technique | |||
| IMRT only | 33 (75%) | 9 (24%) | <0.001 |
| Combined 3D-CRT + IMRT | 9 (20%) | 8 (21%) | |
| 3D-CRT only | 2 (5%) | 21 (55%) | |
| Number of IMRT fields | |||
| Median | 4 | 5 | 0.001 |
| Range | 3–7 | 4–9 | |
| Treatment time | |||
| Median | 49 | 53 | 0.31 |
| Range | 37–68 | 29–180 | |
| Chemotherapy | |||
| Yes | 36 (82%) | 35 (92%) | 0.07 |
| No | 8 (18%) | 3 (8%) | |
| Surgery | |||
| Yes | 4 (9%) | 2 (5%) | 0.51 |
| No | 40 (91%) | 36 (95%) | |
| Lung volume receiving 20 Gy | 23.3% (SD ± 7.2) | 32.2% (SD ± 11.6) | <0.001 |
| Range | 7–38% | 10–58% | |
| Lung volume receiving 10 Gy | 33.5% (SD ± 10.0) | 45.7% (SD ± 15.4) | <0.001 |
| Range | 14–52% | 15–79% | |
| Lung volume receiving 5 Gy | 44.5% (SD ± 13.4) | 61.2% (SD ± 18.9) | <0.001 |
| Range | 16–80% | 19–99% | |
| Mean lung dose | 14.0 Gy (SD ± 5.5 Gy) | 17.6 Gy (SD ± 5.6 Gy) | 0.005 |
| Range | 5.8–39.9 Gy | 5.9–26.2 Gy | |
| Maximum esophagus dose | 56.5 (SD ± 13.6 Gy) | 61.1 (SD ± 14.0 Gy) | 0.07 |
| Range | 6–68.3 Gy | 45.8–70.0 Gy | |
| Mean esophagus dose | 20.8 Gy (SD ± 10.9 Gy) | 34.0 Gy (SD ± 13.7 Gy) | <0.001 |
| Range | 0.9–45.3 Gy | 6.8–60.1 Gy | |
| Esophageal volume receiving 60 Gy | 3.5 (SD ± 5.8 Gy) | 14.5 (SD ± 16.4 Gy) | 0.001 |
| Range | 0–19.0 Gy | 0–58.0 Gy | |
| Mean heart dose | 15.2 Gy (SD ± 10.4 Gy) | 18.6 Gy (SD ± 9.8 Gy) | 0.14 |
| Range | 0.7–39.1 Gy | 0.7–34.3 Gy | |
| Maximum spinal cord dose | 36.2 (SD ± 11.6 Gy) | 42.1 (SD ± 9.3 Gy) | 0.013 |
| Range | 2.1–46.5 Gy | 4.9–49.5 Gy | |