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. 2015 Jun 23;9:158. doi: 10.3389/fnbeh.2015.00158

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Copyright © 2015 Chew, Ryu, Ng, Ma, Dasgupta, Neo, Zhao, Zhong, Bichler, Sajikumar and Goh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knocking down of GSK3β affects contextual memeory. (A) Schematic diagram shows habituation and test procedures for contextual fear memory test. (B) Graph shows percentage of freezing time during various phases of fear training. (C) Graph shows percentage of time freezing across 3 min when mice were placed back in the fear chamber 24 h after training (Student’s-T-test ***p < 0.001). (D) Graphs shows percentage of time freezing when mice were placed in a contextually different chamber but presented with an identical tone (shCon: n = 25, shGSK3: n = 14, error bars SEM).