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. Author manuscript; available in PMC: 2015 Jun 23.
Published in final edited form as: Tuberculosis (Edinb). 2007 Dec 18;88(3):187–196. doi: 10.1016/j.tube.2007.10.006

Figure 1.

Figure 1

Lung TB burden at time intervals after aerosol infection. A) Number of grossly visible granuloma in the lungs of rabbits sacrificed at different time intervals (shown on the X axis). Higher-dose aerosol experiment is shown in black circles. Lower-dose aerosol experiment is shown in grey squares. B) Mean number of CFU (± SE) in the entire right upper lobe of the rabbits sacrificed at different time intervals. The solid line shows the mean log10CFU in Mtb H37Rv-infected untreated rabbits at each time point in the higher-dose experiment. The dotted line shows the results from the lower-dose aerosol experiment. P-values are compared to the 5 week log10CFUs of the same experiment. In the lower-dose experiment, there were fewer granulomas established and the clearance of both granulomas and bacilli was more rapid.