Table II.
No. Weeks after aerosol | No. of rabbits | No. of tubercles | Tubercle diameter (mm) | Lung weight (g) | Right upper lobe CFU (median [range]) | No. rabbits culture-negative at any site |
---|---|---|---|---|---|---|
Higher-Dose Aerosol | ||||||
Week 15 | 6 | 9 ± 4 | 0.7 ± 0.3 | 12.0 ± 0.5 | 4050 [0-23,000] | 2/6 |
P=0.13* | ||||||
Week 20 | 6 | 14 ± 5 | 1.7 ± 0.7 | 13.0 ± 0.7 | 1356 [375-71,000] | 0/6 |
P=0.002* | ||||||
Lower-Dose Aerosol | ||||||
Week 15 | 3 | 30 ± 23 | 1.2 ± 0.3 | 12.2 ± 0.3 | 0 [0-8850] | 2/3 |
Week 25 | 18 | 7 ± 5 | 0.7 ± 0.3 | 12.2 ± 0.4 | 50 [0-6000]** | 3/18 |
P values compared to 5 week values except for those denoted with an asterisk which are compared to the untreated control at the same time point
No P value could be calculated since all RUL homogenates in the control group were culture-negative