Table 3.
Effective rate and Hamilton Depression Rating Scale (HAMD) score of pattern-based Chinese herbal medicine treatment for depression.
| Chinese herbal formula | Type of cases | Mean effective rate in % (range, 95% CI) | Mean HAMD change score (range, 95% CI) |
|---|---|---|---|
| Liver qi depression | |||
| Xiaoyao decoction/pill (N = 4) | Depression (N = 4) | 84.7 (70.0–93.3, 80.8–84.7) | 19.1 (12.8–26.0, 18.4–19.9) |
| Chaihu Shugan decoction (N = 2) | Depression (N = 1); poststroke depression (N = 1) | 90.0 (86.7–93.3, 88.8–91.2) | 15.0 (14.6–15.4, 14.9–15.1) |
| Jieyu Heji (N = 1) | Depression (N = 1) | 51.0 (NA) | NR |
| Yushu pill (N = 1) | Depression (N = 1) | 74.3 (NA) | NR |
| All (N = 8) | 85.1 (51.0–93.3, 77.3–80.9) | 17.7 (12.8–26.0, 17.2–18.63) | |
| Liver depression and spleen deficiency | |||
| Xiaoyao decoction/pill (N = 1) | Depression comorbid diabetes (N = 1) | NR | 7.3 (NA) |
| Yiqiyangyin Shuganjieyu decoction (N = 1) | Depression comorbid diabetes (N = 1) | 83.3 (NA) | 12.1 (NA) |
| Chaihu Shugan decoction (N = 1) | Depression (N = 1) | 92.1 (NA) | NR |
| All (N = 3) | 87.7 (83.3–92.1, 86.2–89.2) | 9.7 (7.3–12.1, 8.9–10.5) | |
| Dual deficiency of the heart and spleen | |||
| Guipi decoction (N = 1) | Depression (N = 1) | NR | NR |
| Xiaochaihu Tang (N = 1) | Depression (N = 1) | NR | NR |
| Anshen Jieyu Fang decoction (N = 1) | Depression comorbid diabetes (N = 1) | NR | 10.7 (NA) |
| Jieyu Yi Hao (N = 1) | Depression (N = 1) | 90.0 (NA) | 11.4 (NA) |
| Shexiang Baoxin pill (N = 1) | Depression (N = 1) | 92.2 (NA) | NR |
| All (N = 5) | 91.5 (90.0–92.2, 91.3–91.6) | 10.8 (10.7–11.4, 10.6–11.0) | |
| Liver depression and qi stagnation | |||
| Chaihu Shugan decoction (N = 2) | Depression (N = 2) | 89.8 (86.7–93.0, 88.8–90.9) | 17.3 (13.9–20.7, 16.2–18.4) |
| Shujiele Wutang pill (N = 1) | Depression (N = 1) | 91.4 (NA) | 18 (NA) |
| All (N = 3) | 90.4 (86.7–93.0, 89.7–91.0) | 17.5 (13.9–20.7, 16.9–18.2) | |
| All studies (N = 18) a | 85.0 (51.0–93.33, 84.1–85.9) | 15.4 (7.3–26.0, 15.0–15.8) |
aOne study studied more than one TCM pattern; NA: not applicable; NR: not reported.