Fig. 5.

The COX-2-dependent upregulations of antioxidant proteins in the hippocampus after intraperitoneal LPS infusion. Representative gels (insert) and densitometric analysis of results from Western blot showing changes in expression of cupper/zinc superoxide dismutase (Cu/ZnSOD) (a), manganese SOD (MnSOD) (b), catalase (c), or glutathione peroxide (GPx) (d) in hippocampus, measured on day 7 after intraperitoneal infusion via an osmotic minipump of saline or LPS (2.5 mg/kg/day) for 7 days alone or with additional intracerebroventricular infusion of NS398 (5 μg/μl/h, dissolved in 1 % DMSO), tempol (2.5 μg/μl/h, dissolved in saline) or the corresponding vehicle. Values are mean ± SEM, n = 8–10 rats per group. *P <0.05 vs. saline-treated group; ^#P <0.05 vs. LPS-treated group in the post hoc Scheffé multiple-range test