Table 1.

Effect of daily bolus injection of NS398 (10 mg/kg, i.p.) on the increases in plasma proinflammatory cytokine levels following intraperitoneal infusion of Escherichia coli lipopolysaccharide (LPS, 2.5 mg/kg/day) for 7 days

Cytokines	Treatment
(pg/ml)	Saline	LPS	LPS + DMSO	LPS + NS398
IL-1β	485 ± 62	1086 ± 135*	1226 ± 165*	637 ± 88**
IL-6	567 ± 83	1669 ± 231*	1450 ± 204*	709 ± 74**
TNF-α	68 ± 11	127 ± 22*	136 ± 24*	75 ± 18**

Data are mean ± S.E.M., n = 6-8 animals per group

^* P < 0.05 versus saline group; ^** P < 0.05 versus LPS group in the Scheffé multiple-range test