Table 1.
Neuroendocrine responses and NEFA responses during euglycemic and hypoglycemic clamps
| Day 1 euglycemia |
Day 2 hypoglycemia
after day 1 euglycemia |
Day 1 hypoglycemia |
Day 2 hypoglycemia
after day 1 hypoglycemia |
|||||
|---|---|---|---|---|---|---|---|---|
| Basal | Final | Basal | Final | Basal | Final | Basal | Final | |
| Epinephrine (pmol/L) | 190 ± 20 | 189 ± 20 | 179 ± 20 | 4,251 ± 568*† | 184 ± 40 | 3,741 ± 465*† | 198 ± 30 | 2,497 ± 265*†‡ |
| Norepinephrine (pmol/L) | 1,083 ± 80 | 1,159 ± 77 | 1,128 ± 124 | 1,957 ± 134* | 1,057 ± 119 | 1,966 ± 149* | 1,161 ± 124 | 2,028 ± 184* |
| Cortisol (nmol/L) | 344 ± 31 | 292 ± 30 | 330 ± 32 | 714 ± 42*† | 359 ± 34 | 850 ± 70*† | 271 ± 26 | 572 ± 62*†‡ |
| Glucagon (ng/L) | 65 ± 5 | 43 ± 3* | 50 ± 6 | 112 ± 17*† | 57 ± 4 | 164 ± 26*† | 44 ± 7 | 90 ± 13*†‡ |
| GH (ng/mL) | 2.5 ± 0.4 | 2.4 ± 0.4 | 4 ± 1.34 | 25 ± 5*† | 3.1 ± 0.5 | 28 ± 5* | 2.2 ± 0.2 | 20 ± 3*† |
| NEFA (mmol/L) | 379 ± 48 | 103 ± 40* | 382 ± 55 | 97 ± 14* | 288 ± 32 | 110 ± 19* | 351 ± 28 | 98 ± 23* |
Data are means ± SE. GH, growth hormone.
*P < 0.05, significantly different from baseline.
†P < 0.05, significantly different from day 1 euglycemia.
‡P < 0.05, significantly different from day 1 hypoglycemia.