Table 3.
Cardiovascular responses during hyperinsulinemic-euglycemic and hyperinsulinemic-hypoglycemic clamps
| Basal | Final | |
|---|---|---|
| Systolic blood pressure (mmHg) | ||
| Day 1 eugly | 110 ± 3 | 110 ± 3 |
| Day 2 hypo after day 1 eugly | 109 ± 3 | 116 ± 4 |
| Day 1 hypo | 112 ± 4 | 121 ± 7† |
| Day 2 hypo after day 1 hypo | 113 ± 4 | 123 ± 5†‡ |
| Diastolic blood pressure (mmHg) | ||
| Day 1 eugly | 63 ± 2 | 62 ± 2 |
| Day 2 hypo after day 1 eugly | 65 ± 1 | 60 ± 2† |
| Day 1 hypo | 65 ± 2 | 62 ± 3 |
| Day 2 hypo after day 1 hypo | 66 ± 1 | 62 ± 2† |
| Mean arterial pressure (mmHg) | ||
| Day 1 eugly | 79 ± 2 | 76 ± 3 |
| Day 2 hypo after day 1 eugly | 80 ± 2 | 80 ± 2 |
| Day 1 hypo | 81 ± 3 | 82 ± 4 |
| Day 2 hypo after day 1 hypo | 81 ± 2 | 83 ± 3 |
| Heart rate (bpm) | ||
| Day 1 eugly | 64 ± 3 | 67 ± 2 |
| Day 2 hypo after day 1 eugly | 65 ± 3 | 74 ± 2†‡ |
| Day 1 hypo | 66 ± 3 | 70 ± 3 |
| Day 2 hypo after day 1 hypo | 68 ± 3 | 75 ± 2†‡ |
Data are means ± SE. eugly, euglycemia; hypo, hypoglycemia.
†P < 0.05 compared with baseline.
‡P < 0.05 compared with final euglycemia.