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. 2015 Feb 9;64(7):2457–2466. doi: 10.2337/db14-1364

Figure 2.

Figure 2

Mean ± SEM concentration of insulin in plasma and CSF and glucose in plasma at different time points after 0.5 units/kg i.p. DET or NPH insulin in rats. Plasma insulin rose rapidly after the intraperitoneal injection of NPH insulin, peaking at 5 min and then decreasing (A). CSF insulin levels also rose rapidly after intraperitoneal NPH insulin, the peak occurring at around 40 min and levels returning to baseline by 320 min (B). Plasma glucose dropped sharply after intraperitoneal NPH insulin, returning to baseline by 80 min (C). Intraperitoneal DET also increased plasma insulin after 5 min, and it remained elevated at a relatively constant level throughout the 320 min (D). CSF insulin peaked rapidly after intraperitoneal DET at the 5- and 10-min time points before reducing to a stable but elevated level between 40 and 320 min (E). Plasma glucose was reduced after DET to a constant level for the duration of the experiment (F). Significant differences are described in the text.