Table 1.
Key components of Drosophila canonical signaling pathways
| Pathway | Receptor | Ligand | Transcription factor |
|---|---|---|---|
| Hormone receptors | e.g., EcR | e.g., Ecdysone | EcR |
| Notch | Notch | Delta, Serrate | Su(H) |
| JAK STAT | Domeless | Upd, Upd2, Upd3 | STAT92E |
| RTK | EGFR | Spitz, Kerren, Gurken, Vein | Pointed, Yan, Cic |
| FGFR (breathless) | Branchless, Heartless, Thisbe, Pyramus | Pointed,Yan | |
| InR | Dilp1-Dilp7 | Pointed, Yan, Foxo | |
| PVR | Pvf1-3 | Pointed,Yan | |
| Torso | Trunk, PTTH | Pointed,Yan | |
| ALK | Jelly belly | Pointed,Yan | |
| Sev | Boss | Pointed,Yan | |
| Hh | Patched | Hh | Ci |
| TGFβ (BMP) | Thickveins, Saxophone, Baboon, punt | Dpp, Gbb | Mad, Medea, Smox |
| Hippo | Fat | Dachsous | Yorkie |
| NF-κB | Toll | Spatzle | Dorsal |
| JNK | Eiger | Wengen | Jun, Fos |
| Wnt | Fz, Fz2, Fz3 | Wg, Wnt1-10 | Armadillo, Pan (TCF) |