. 2015 Feb 23;10(6):1425–1434. doi: 10.1021/cb5008647

Table 1. MIC of Inhibitor Compounds against A. fumigatus^a.

strains		WT	NMT
growth conditions	BMT +	0.56 mM Glc	0.56 mM Glc	3.33 mM Glc	55.5 mM Glc	111 mM Glc
level of NMT repression	nmt transcription (%)	100 ± 4	81 ± 10	78 ± 15	29 ± 7	24 ± 1
MIC (mM)	DDD86481	0.925	0.116	0.058	0.014	0.007
	DDD85646	>2.5	>2.5	ND	>2.5	>2.5
	DDD90086	>2.5	1.25	ND	0.625	0.625
	Ro-09-4609	>2.5	>2.5	ND	>2.5	>2.5
	Ro-09-4879	0.625	0.625	ND	0.625	0.625
	other compounds*	>2.5	>2.5	ND	ND	ND
	amphotericin B	0.0017	0.0017	0.0017	0.0017	0.0017

The CLSI broth microdilution method was used to determine the MIC (lowest concentration that completely inhibited growth) after 48 h of incubation at 37 °C. BMT, basic medium plus 0.1 M threonine; Glc, glucose; ND, not determined; *All other compounds listed in the Supporting Information, Table 2.

Table 1. MIC of Inhibitor Compounds against A. fumigatusa.

Table 1. MIC of Inhibitor Compounds against A. fumigatus^a.