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. 2015 Mar 12;43(11):e73. doi: 10.1093/nar/gkv202

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — Genetic and site-specific display of unnatural amino acids (UAAs) on the envelope of lentiviral vectors. (A) The structure of lentiviral VSVg protein. Total 33 residues, marked in red, within VSVg were mutated in this study. (B) Schematic representative of lentiviral vector engineering via genetic code expansion for site-specific incorporation of UAAs (NAEK or DiZPK) on the vector surface. (C) Schematic representation of genetic code expansion for site-specific incorporation of UAAs. The UAAs were incorporated into VSVg protein via UAG-code and an orthogonal aaRS/tRNA.