Table 1. Co-Evolution Order (CEO) and Coefficient of Assortativity (CoA) at three different domains of 16S rRNA.

16S rRNA domain	CEO (all CEPs)	CEO (non-steric CEPs)	CoA (all CEPs)	CoA (non-steric CEPs)
5′-Domain	136.05	60.08	0.785 (10E−54)	0.591 (10E−63)
Central domain	97.50	32.45	0.871 (10E−43)	0.708 (10E−35)
3′-Domain	192.75	159.57	0.615 (10E−32)	0.408 (10E−21)

The values in the parenthesis indicate the statistical significance of CoA value. Our results show that co-evolutionary patterns within SSU mimic the topology of small proteins according to local folding rates.