Table 4.
Health-related quality of life after lifestyle interventions
| Reference | Study characteristics | Total no. of subjects | Body composition measure | Dietary measure | Physical activity measure | HRQoL measure | Mean difference between groups at 12 mo/coefficient (95% CI) | Covariates included |
|---|---|---|---|---|---|---|---|---|
| von Gruenigen et al. (2008)34; von Gruenigen et al. (2009)35 | RCT | 45 ITT | BMI measured | 3-day dietary records performed on 1 weekend and 2 weekdays at 3, 6, & 12 mo | 4-item leisure score index from Godin Leisure-Time Exercise Questionnaire, (classified as mild,moderate, or strenuous) | FACIT-F | Effect size at 12 mo (LI–UC) | Baseline measurement |
| Stage I/II endometrial cancer | Response rate: 40% | Effect size at 12 mo (LI–UC): BMI, | Effect size at 12 mo (LI–UC): total intake, −90 kcal; vitamin C | Effect size at 12 mo (LI–UC): LSI, 15.8**; pedometer, NR | HRQoL | −0.14 (−0.61 to 0.33) | ||
| LI for 6 mo vs UC | Attrition rate: 16% | −0.5 kg/m2; weight, −4.9 kg* | intake, 15.6 mg; folate intake, 101.4 μg) | Physical WB | −0.10 (−0.57 to 0.38) | |||
| FU: 12 mo | Completion rate: 80% | Functional WB | −0.13 (−0.61 to 0.35) | |||||
| Type I EC: 100% | Adherence rate: 73% | Emotional WB | −0.29 (−0.77 to 0.18) | |||||
| Social WB | 0.10 (−0.38 to 0.57) | |||||||
| Fatigue | −0.15 (−0.62 to 0.32) | |||||||
| SF-36 | NR | |||||||
| McCarroll et al. (2013)32; von Gruenigen et al. (2012)33 | RCT | 75 ITT | BMI measured | Two 24-h recalls: 1 classified as FV servings/d and 1 classified as kcal/d | Four-item LSI from Godin Leisure-Time Exercise Questionnaire, along with duration questions 7-day pedometer step test at baseline and 6 mo | FACT-G (assessed at baseline and 3, 6, and 12 mo) | Fatigue at 3 mo significantly different between groups, P = 0.008 | Age, time since diagnosis, stage, adjuvant treatment, comorbidities, and baseline measurement |
| Stage I/II endometrial cancer | Response rate: 19% | Body composition using DXA (NR) | Physical function at 6 mo significantly different between groups, P = 0.048 | |||||
| LI for 6 mo vs UC | Attrition rate: 21% | Biomarkers (NR) | Total FACT-G score was improved in the LI group from baseline to 3 mo (P < 0.05) and 6 mo (P < 0.001) | |||||
| FU: 12 mo | Completion rate: 78% | Effect size at 12 mo (LI–UC): BMI, −1.8 kg/m2; weight, −4.6 kg***; waist circum., −1.6 cm* | Effect size at 12 mo (LI–UC): total intake, −187 kcal***; FV, 0.9 servings/d*** | Effect size at 12 mo (LI–UC): LSI, 7.8 points***; minutes of PA, 89 min/wk***; pedometer, not measured at 12 mo | ||||
| Type I EC: 100% | Adherence rate: 84% |
Abbreviations: BMI, body mass index; circum., circumference; DXA, dual-energy X-ray absorptiometry; EC, endometrial cancer; FACIT-F, Functional Assessment of Chronic Illness Therapy–Fatigue; FACT-G, Functional Assessment for Cancer Therapy–General; FV, fruits and vegetables; FU, follow-up; ITT, intention-to-treat analysis; LI, lifestyle intervention; LSI, Leisure Score Index; NR, not reported; RCT, randomized controlled trial; Vit C, vitamin C; UC, usual care; WB, well-being.
*P < 0.05, significant compared with baseline; **P < 0.05, significant between groups; ***P < 0.001, between groups.