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. Author manuscript; available in PMC: 2015 Jun 23.
Published in final edited form as: Br J Haematol. 2014 Mar 12;165(6):842–853. doi: 10.1111/bjh.12827

Table III.

Summary of key findings in drug-free specimens. AA=arachidonic acid, ADP=adenosine diphosphate, COLL=collagen, EPI=epinephrine, RIST=ristocetin, THROMB=thrombin, TRAP=thrombin receptor activating peptide

Platelet-rich plasma Whole blood
Chrono-Log BioData Aggregation Chrono-Log Multiplate Aggregation
Aggregation ATP Release Aggregation ATP Release




Males versus females EPI↓ EPI↓ EPI↓
Blacks versus Whites RIST↓ COLL↓
THROMB↓
ADP↑ COLL↓
THROMB↓
AA↓
Flavonoid-rich food exposure AA↓
ADP↓
COLL↓
AA↓
ADP↓
AA↓
ADP↓
COLL↓
AA↓
ADP↓
COLL↓
AA↓
ADP↓
COLL↓
THROMB↓
AA↓
ADP↓
COLL↓
TRAP↓
Intra-individual variability (range of median CVs among agonists used) 8.6–13.8 17.2–40.4 4.8–12.2 19.0–26.8 21.4–35.1 14.6–25.3
Profiles abnormal with:
 1 agonist 21% 19% (28%*) 13% 15% 25% (30%*) 6%
 >1 agonist 9% 5% (10%*) 2% 4% 10% (14%*) 0
*

profiles including both aggregation and ATP release