Table III.
Summary of key findings in drug-free specimens. AA=arachidonic acid, ADP=adenosine diphosphate, COLL=collagen, EPI=epinephrine, RIST=ristocetin, THROMB=thrombin, TRAP=thrombin receptor activating peptide
| Platelet-rich plasma | Whole blood | |||||
|---|---|---|---|---|---|---|
| Chrono-Log | BioData Aggregation | Chrono-Log | Multiplate Aggregation | |||
| Aggregation | ATP Release | Aggregation | ATP Release | |||
|
|
|
|
|
|||
| Males versus females | EPI↓ | EPI↓ | EPI↓ | |||
| Blacks versus Whites | RIST↓ | COLL↓ THROMB↓ |
ADP↑ | COLL↓ THROMB↓ AA↓ |
||
| Flavonoid-rich food exposure | AA↓ ADP↓ COLL↓ |
AA↓ ADP↓ |
AA↓ ADP↓ COLL↓ |
AA↓ ADP↓ COLL↓ |
AA↓ ADP↓ COLL↓ THROMB↓ |
AA↓ ADP↓ COLL↓ TRAP↓ |
| Intra-individual variability (range of median CVs among agonists used) | 8.6–13.8 | 17.2–40.4 | 4.8–12.2 | 19.0–26.8 | 21.4–35.1 | 14.6–25.3 |
| Profiles abnormal with: | ||||||
| 1 agonist | 21% | 19% (28%*) | 13% | 15% | 25% (30%*) | 6% |
| >1 agonist | 9% | 5% (10%*) | 2% | 4% | 10% (14%*) | 0 |
profiles including both aggregation and ATP release