Skip to main content
. Author manuscript; available in PMC: 2016 Jun 3.
Published in final edited form as: Tetrahedron Lett. 2015 Jun 3;56(23):3620–3623. doi: 10.1016/j.tetlet.2015.01.074

Table 2.

Optimization of acylation conditions.

graphic file with name nihms-657300-f0007.jpg
Entry Base Solvent temp (°C) conc. (M) Yield (%)
1 NaOt-Bu DME rt 0.1 27
2 NaH DME rt 0.1 74
3 KOt-Bu DME rt 0.1 63
4 n-BuLi THF –78 0.1 n.d.
5 n-BuLi THF 0 0.1 n.d.
6 i-PrMgCl THF 0 0.1 90a
7 i-PrMgCl THF 0 0.2 74

DME = 1,2-dimethoxyethane