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. Author manuscript; available in PMC: 2016 Jun 3.
Published in final edited form as: Tetrahedron Lett. 2015 Jun 3;56(23):3620–3623. doi: 10.1016/j.tetlet.2015.01.074

Table 3.

Exploration of solvents for tropane alkylation.

graphic file with name nihms-657300-f0008.jpg
Entry Solvent Temp (°C) Time (h) Yield (%)
1 DMSO rt 24 n.d.
2 DMF rt 12 56
3 NMP rt 12 44
4 Acetonitrile rt 12 58
5 Acetonitrile 75 6 62
6 Acetonitrile 75 12 56

DMSO = dimethylsulfoxide; DMF = N,N-dimethylformamide; NMP = N-methyl-2-pyrolidinone