Table 1.
Patient characteristics at baseline (before randomization)
| PMX-treated group (n = 119) | Standard treatment (n = 113) | |
|---|---|---|
| Age (years) | 71.5 (19–90) | 72 (39–94) |
| Male–female ratio, no. (%) | 72 (60)–47 (40) | 62 (55)–51 (45) |
| SAPS2 | 57 (25–107) | 59 (21–116) |
| SOFA score | 10 (3–15) | 10 (5–14) |
| McCabe 1, no. (%) | 73 (61) | 71 (63) |
| McCabe 2, no. (%) | 45 (38) | 38 (34) |
| McCabe 3, no. (%) | 1 (1) | 4 (4) |
| Body weight (kg) | 74 (43–185) | 78 (40–137) |
| Pre-existing conditions, no. (%) | ||
| Hypertension | 69 (58) | 63 (56) |
| Cardiac failure | 13 (11) | 13 (12) |
| Diabetes | 24 (20) | 20 (18) |
| Chronic renal disorders | 2 | 3 |
| Cancer or hematological malignancy | ||
| Remission | 21 (18) | 23 (20) |
| Evolutive | 14 (12) | 10 (9) |
| Heart rate (beat/min) | 112 (61–177) | 105 (60–168) |
| Systolic arterial pressure (mmHg) | 90 (45–150) | 93 (45–183) |
| Diastolic arterial pressure (mmHg) | 50 (26–80) | 50 (15–95) |
| Mean arterial pressure (mmHg) | 64 (31–93) | 65 (28–96) |
| Leukocytes count (103/mL) | 8.9 (0.5–43.3) | 8.9 (0.3–39.6) |
| Platelets count (103/mL) | 216 (35–931) | 217 (30–700) |
| INR | 1.64 (1.10–4.90) | 1.70 (1.10–3.10) |
| Plasma creatinine (µmol/L) | 133 (38–570) | 133 (30–464) |
| Bilirubin (µmol/L) | 15 (2–142) | 15 (2–132) |
| Lactates (mmol/L) | 2.9 (0.7–13.0) | 3.1 (0.5–13.0) |
| Plasma IL-6 (pg/mL) | 2,146 (107–9,717) | 1,927 (540–9,757) |
| Mechanical ventilation, no. (%) | 117 (98) | 110 (97) |
| pH | 7.29 (6.91–7.50) | 7.28 (6.86–7.47) |
| PaO2/FiO2 | 219 (46–573) | 197 (63–659) |
| Norepinephrine infusion, no. (%) | 119 (100) | 113 (100) |
| Norepinephrine infusion rate (µg/kg/min) | 0.44 (0.04–5.00) | 0.41 (0.30–11.40) |
| Epinephrine infusion, no. (%) | 1 (1) | 7 (6) |
| Dobutamine infusion, no. (%) | 6 (3) | 2 (2) |
| Fluid therapy before randomization (mL) | 4,497 (354–14,723) | 4,000 (500–13,232) |
Values expressed as median with minimum–maximum (min–max) or in number and percentage (%). Numerical values are expressed as median (min–max) except for IL-6 median (interquartile range)
SAPS simplified acute physiologic score, INR international normalized ratio