Table 4.
Logistic Regression Modeling of Neurocognitive Impairment Outcomes for Targeted SNPs
| Neurocognitive Outcome | Gene Symbol (refSNP) | Univariable OR (95% CI) | P | Multivariable OR (95% CI) | P | Q |
|---|---|---|---|---|---|---|
| Wechsler IQ | NOS3 (rs1799983) | 3.33 (1.35 to 8.32) | .009 | 5.07 (1.80 to 14.28) | .002 | 0.008 |
| SLCO2A1 (rs7625035) | 2.23 (1.09 to 4.55) | .028 | 2.67 (1.20 to 5.92) | .016 | 0.043 | |
| Wechsler Digit Span | SLCO2A1 (rs7625035) | 2.35 (1.41 to 3.91) | <.001 | 2.55 (1.48 to 4.40) | <.001 | 0.006 |
| Wechsler Vocabulary | NOS3 (rs1799983) | 3.21 (1.39 to 7.41) | .006 | 3.94 (1.54 to 10.09) | .004 | 0.011 |
| Wechsler Block Design | SLCO2A1 (rs7625035) | 2.00 (0.92 to 4.34) | .080 | 2.40 (1.05 to 5.48) | .038 | 0.076 |
| Wechsler Matrix Reasoning | NOS3 (rs1799983) | 4.33 (1.30 to 14.42) | .017 | 15.65 (2.80 to 87.66) | .002 | 0.008 |
| Attention (BASC-2) | COMT (rs4680) | 2.24 (1.12 to 4.48) | .023 | 2.61 (1.26 to 5.45) | .010 | 0.080 |
| SLCO2A1 (rs7625035) | 1.99 (1.16 to 3.40) | .013 | 2.04 (1.17 to 3.57) | .013 | 0.043 | |
| Hyperactivity (BASC-2) | COMT (rs4680) | 2.07 (0.94 to 4.55) | .070 | 2.71 (1.17 to 6.31) | .021 | 0.084 |
NOTE. Univariable and multivariable ORs for abnormal scores, as defined in the methods, were calculated, adjusting for the effects of age at diagnosis, sex, risk group, race, CNS prophylaxis (radiation v intrathecal chemotherapy), corticosteroid (prednisone v dexamethasone), and socioeconomic status. For each neurocognitive or behavioral outcome, genetic variants with an FDR Q value < 0.10 multivariable OR are shown, and a complete table is included as a Data Supplement.
Abbreviations: BASC-2, Behavioral Assessment System for Children–2; FDR, false discovery rate; OR, odds ratio; SNP, single nucleotide polymorphism.