Table A1.
Comparison of Patients Included in Genetic Analyses and Remaining Patients Enrolled Onto 95-01 or 00-01
| Characteristic | Neurocognitive and Genetic Testing Done, No. (%) | Remaining Patients, No. (%) | P |
|---|---|---|---|
| No. | 350 | 633 | |
| DFCI ALL consortium treatment protocol | |||
| 95-01 | 209 (60) | 282 (45) | < .001 |
| 00-01 | 141 (40) | 352 (55) | |
| Age at initial diagnosis, years; median (range) | 4.2 (1-17.99) | 5.1 (1-17.9) | |
| < 5 | 210 (60) | 313 (49) | < .001 |
| 5-9.99 | 93 (27) | 168 (27) | |
| 10-17.99 | 47 (13) | 152 (24) | |
| Sex | |||
| Female | 159 (45) | 287 (45) | .99 |
| Male | 191 (55) | 346 (55) | |
| DFCI risk group | |||
| Standard risk | 225 (64) | 329 (52) | < .001 |
| High risk | 125 (36) | 304 (48) | |
| Race/ethnicity | |||
| White | 308 (88) | 537 (85) | .053 |
| Black or African American | 8 (2) | 37 (6) | |
| Asian | 6 (2) | 7 (1) | |
| Other/unknown | 28 (8) | 52 (8) | |
| Hispanic | 25 (7) | 73 (12) | .034 |
| CNS prophylaxis | |||
| Intrathecal chemotherapy | 176 (50) | 245 (39) | |
| Cranial radiation (12 or 18 Gy) | 156 (45) | 276 (44) | |
| Did not receive | 18 (5) | 112 (18) | |
| Corticosteroids | |||
| Prednisone | 277 (79) | 489 (77) | .69 |
| Dexamethasone | 73 (21) | 139 (22) | |
| Did not receive | 0 (0) | 5 (1) | |
| Age at time of neurocognitive testing, years; median (range) | 10 (6, 25) | — | |
| Mother's education | |||
| High school graduate/GED or less | 89 (25) | — | |
| Some college or more | 251 (72) | — | |
| Unknown | 10 (3) | — | |
| Time from diagnosis to neurocognitive testing, years; median (range) | 5 (3-9) |
NOTE. The observed differences between these cohorts are a function of the study design. Neurocognitive testing was conducted among survivors, 5 years after diagnosis. Patients with induction failure, death, or early relapse were therefore excluded from analysis. Consequently, one would expect high-risk features (eg, older age) to be more prevalent among the group who did not undergo neurocognitive testing. Nevertheless, it seems unlikely that any selection bias would have systematically altered relationships among genetic variants and neurocognitive outcomes. Dashes indicate data not collected.
Abbreviations: ALL, acute lymphoblastic leukemia; DFCI, Dana-Farber Cancer Institute; GED, general educational development.