Table 2.
Association between demographic/clinical factors and chemotherapy doses for the palliative intent group (N = 321) and curative intent group (N = 179).
| Variable | Curative intent group
|
Palliative intent group
|
||||
|---|---|---|---|---|---|---|
| Primary dose reduction (n = 26) | Standard dose (n = 153) | p-Value | Primary dose reduction (n = 81) | Standard dose (n = 240) | p-Value | |
| Age, years | ||||||
| Mean (range) | 78.5 (66–89) | 72.1 (65–87) | <0.01 | 75.8 (65–91) | 72.3 (65–89) | <0.001 |
| SD | 6.6 | 5.5 | 6.8 | 5.8 | ||
| No. (%) | No. (%) | No. (%) | No. (%) | |||
| Gender | ||||||
| Male | 9 (35) | 55 (36) | 0.90 | 39 (48) | 116 (48) | 0.98 |
| Female | 17 (65) | 98 (64) | 42 (52) | 124 (52) | ||
| Race | ||||||
| White | 24 (92) | 120 (78) | 0.10 | 74 (91) | 208 (87) | 0.26 |
| Non-White | 2 (8) | 33 (22) | 7 (9) | 32 (13) | ||
| BMI | ||||||
| <25 | 19 (73) | 69 (45) | 0.008 | 45 (56) | 120 (50) | 0.42 |
| ≥25 | 7 (27) | 84 (55) | 36 (44) | 118 (50) | ||
| Missing | ||||||
| Marital status | ||||||
| Married | 14 (54) | 95 (62) | 0.43 | 46 (57) | 151 (63) | 0.33 |
| Widowed | 10 (38) | 33 (22) | 0.06 | 22 (27) | 48 (20) | 0.18 |
| Household composition | ||||||
| Living alone | 9 (35) | 30 (20) | 0.10 | 18 (23) | 49 (20) | 0.69 |
| Other | 17 (65) | 120 (80) | 62 (77) | 191 (80) | ||
| Missing | 3 | 1 | ||||
| Cancer type | ||||||
| Breast | 0 (0) | 39 (25) | <0.01 | 4 (5) | 14 (6) | 0.99 |
| GI | 9 (35) | 45 (29) | 0.59 | 23 (28) | 58 (24) | 0.45 |
| GU | 2 (8) | 9 (6) | 0.66 | 13 (16) | 26 (11) | 0.21 |
| GYN | 11 (42) | 27 (18) | <0.01 | 15 (19) | 34 (14) | 0.35 |
| Lung | 4 (15) | 27 (18) | 0.99 | 21 (26) | 91 (38) | 0.05 |
| Comorbid conditions | ||||||
| Arthritis | 14 (54) | 74 (48) | 0.61 | 34 (42) | 107 (45) | 0.68 |
| Circulatory problem | 5 (19) | 16 (10) | 0.20 | 15 (19) | 40 (17) | 0.70 |
| Depression | 4 (15) | 17 (11) | 0.53 | 18 (22) | 28 (12) | 0.02 |
| Diabetes mellitus | 3 (12) | 28 (18) | 0.40 | 10 (12) | 40 (17) | 0.35 |
| Emphysema | 3 (12) | 10 (7) | 0.36 | 10 (12) | 31 (13) | 0.89 |
| Glaucoma | 1 (4) | 19 (12) | 0.32 | 12 (15) | 17 (7) | 0.04 |
| Hypertension | 12 (46) | 83 (54) | 0.44 | 45 (56) | 119 (50) | 0.35 |
| Heart disease | 6 (23) | 25 (16) | 0.40 | 26 (32) | 44 (18) | 0.01 |
| Liver/kidney disease | 1 (4) | 2 (1) | 0.38 | 13 (16) | 6 (3) | <0.01 |
| Other cancers | 6 (23) | 23 (15) | 0.30 | 28 (35) | 35 (15) | <0.01 |
| Osteoporosis | 10 (38) | 27 (18) | 0.02 | 13 (16) | 33 (14) | 0.61 |
| Stomach disorders | 3 (12) | 26 (17) | 0.77 | 24 (30) | 42 (18) | 0.02 |
| Stroke | 1 (4) | 6 (4) | 0.99 | 5 (6) | 5 (2) | 0.07 |
| Mean (range) | Mean (range) | Mean (range) | Mean (range) | |||
|
| ||||||
| SD | 21.0 | 23.7 | 26.1 | 26.5 | ||
| IADL | 13.2 (4–14) | 13.3 (8–14) | 0.65 | 12.7 (7–14) | 12.7 (5–14) | 0.84 |
| SD | 2.0 | 1.3 | 1.8 | 2.0 | ||
| MD KPS | 83.2 (50–100) | 88.2 (60–100) | 0.03 | 82.8 (60–100) | 83.4 (50–100) | 0.65 |
| SD | 12.5 | 9.7 | 11.7 | 11.7 | ||
| Self-rated KPS | 90 (60–100) | 89.6 (50–100) | 0.87 | 81.3 (40–100) | 83.9 (50–100) | 0.14 |
| SD | 11.5 | 12.3 | 14.4 | 13.7 | ||
| Falls | 0.3 (0–3) | 0.3 (0–3) | 0.64 | 0.6 (0–6) | 0.2 (0–4) | 0.02 |
| SD | 0.8 | 0.7 | 1.2 | 0.6 | ||
| Social activity | 57.6 (25–94) | 61.0 (0–100) | 0.44 | 51.2 (0–100) | 54.6 (0–100) | 0.31 |
| SD | 17.2 | 21.3 | 27.2 | 22.2 | ||
| Social support | 80.3 (41–100) | 84.7 (0–100) | 0.34 | 84.4 (10–100) | 85.6 (0–100) | 0.65 |
| SD | 18.1 | 22.1 | 21.0 | 21.4 | ||
| BOMC (≥11) N (%) | 2 (3) | 20 (8) | 0.08 | |||
Abbreviations: SD, standard deviation; BMI, body mass index; GI, gastrointestinal; GYN, gynecologic; GU, genitourinary; MOS, Medical Outcomes Study; IADL, instrumental activities of daily living; KPS, Karnofsky Performance Status; BOMC, Blessed Orientation-Memory-Concentration.