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. Author manuscript; available in PMC: 2015 Jun 23.
Published in final edited form as: Natl Sci Rev. 2015 Feb 15;2(2):217–225. doi: 10.1093/nsr/nwv009

Figure 2. Relationship and comparison between ESCs and 2C-like cells.

Figure 2

Embryonic stem cells (ESCs) can cycle in and out of a transient 2-cell embryo-like (2C-like) state. The population of 2C-like cells at a given time point are less than 0.5% under standard ESC culture conditions. The known regulators of the 2C-like state are listed, all of which are repressors. The different cellular and molecular features of 2C-like cells and ESCs are listed at the bottom.