Table 2. The allele and genotype frequencies of IL-12B gene polymorphisms in AS cases and controls.
| SNPs | HWE | Allele | Genotypic frequency | Allele frequency | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Group | χ2 | p value | 1 | 2 | 11 | 12 | 22 | χ2 | p value | 1 | 2 | χ2 | p value | OR (95%CI) | |
| rs10045431 | Case | A | C | 9(0.022) | 75(0.188) | 316(0.790) | 3.411 | 0.182 | 93(0.116) | 707(0.884) | 2.156 | 0.142 | 1.273(0.922–1.757) | ||
| Control | 0.076 | 0.783 | 3(0.008) | 68(0.172) | 324(0.820) | 74(0.094) | 716(0.906) | ||||||||
| rs11167764 | Case | A | C | 4(0.010) | 95(0.238) | 301(0.752) | 2.512 | 0.285 | 103(0.129) | 697(0.871) | 1.585 | 0.208 | 0.833(0.627–1.107) | ||
| Control | 0.002 | 0.988 | 9(0.023) | 101(0.256) | 285(0.722) | 119(0.151) | 671(0.849) | ||||||||
| rs3212227 | Case | G | T | 73(0.182) | 196(0.490) | 131(0.328) | 0.535 | 0.765 | 342(0.427) | 458(0.573) | 0.223 | 0.637 | 0.953(0.7821–1.163) | ||
| Control | 0.599 | 0.438 | 80(0.203) | 187(0.473) | 128(0.324) | 347(0.439) | 443(0.561) | ||||||||
| rs6556412 | Case | A | G | 68(0.170) | 201(0.503) | 131(0.328) | 0.209 | 0.901 | 337(0.421) | 463(0.579) | 0.101 | 0.751 | 0.968(0.793–1.182) | ||
| Control | 0.010 | 0.919 | 72(0.182) | 195(0.494) | 128(0.324) | 339(0.421) | 451(0.571) | ||||||||
| rs6556416 | Case | A | C | 7(0.018) | 75(0.188) | 318(0.795) | 1.967 | 0.374 | 89(0.111) | 711(0.889) | 1.335 | 0.247 | 1.211(0.875–1.677) | ||
| Control | 0.076 | 0.783 | 3(0.008) | 68(0.172) | 324(0.820) | 74(0.094) | 716(0.906) | ||||||||
| rs6871626 | Case | A | C | 49(0.122) | 156(0.390) | 195(0.487) | 6.942 | 0.031 | 254(0.318) | 546(0.682) | 1.063 | 0.302 | 1.119(0.904–1.385) | ||
| Control | 2.164 | 0.141 | 28(0.071) | 176(0.446) | 191(0.484) | 232(0.294) | 558(0.706) | ||||||||
| rs6887695 | Case | C | G | 61(0.152) | 200(0.500) | 139(0.347) | 0.338 | 0.844 | 322(0.403) | 478(0.598) | 0.265 | 0.607 | 0.949(0.777–1.159) | ||
| Control | 0.188 | 0.665 | 66(0.167) | 196(0.496) | 133(0.337) | 328(0.415) | 462(0.585) | ||||||||
| rs7709212 | Case | C | T | 77(0.193) | 195(0.487) | 128(0.320) | 1.332 | 0.514 | 349(0.436) | 451(0.564) | 1.067 | 0.302 | 0.901(0.739–1.098) | ||
| Control | 0.898 | 0.343 | 89(0.225) | 187(0.473) | 119(0.301) | 365(0.462) | 425(0.538) | ||||||||
SNPs: Single nucleotide polymorphisms; HWE: Hardy-Weinberg equilibrium; OR:odds ratio.
P-value was survived after Bonferroni correction.