Table 2.

Lung cancer risk among bricklayers, the SYNERGY study, 1985–2010

	Cases	Controls	OR1	(95% CI)	OR2	(95% CI)	OR3	(95% CI)
All subjects	15,608	18,531
Never bricklayers	14,913	18,062	1.00	(Reference)	1.00	(Reference)
Never bricklayers, blue collars	11,750	12,275					1.00	(Reference)
Ever bricklayers	695	469	1.47	(1.28–1.68)	1.32	(1.14–1.52)	1.37	(1.19–1.57)
Length of employment as bricklayers
<10 years	278	225	1.20	(0.98–1.47)	1.10	(0.90–1.36)	1.13	(0.92–1.38)
10–19 years	111	63	1.55	(1.09–2.20)	1.37	(0.96–1.94)	1.43	(1.01–2.03)
20–29 years	88	55	1.73	(1.17–2.56)	1.53	(1.03–2.26)	1.60	(1.08–2.37)
30–39 years	99	45	2.43	(1.61–3.66)	2.12	(1.40–3.20)	2.24	(1.48–3.37)
≥40 years	89	55	1.81	(1.22–2.69)	1.58	(1.06–2.35)	1.68	(1.13–2.49)
Unknown	30	26	–	–	–	–	–	–
Test for linear trend (p-value)			<0.001		<0.001		<0.001
Test for linear trend among bricklayers only (p-value)			0.005		0.016		–1
Length of employment as bricklayers, log (years)
Among all subjects	15,578	18,505	1.19	(1.13–1.25)	1.14	(1.08–1.20)	1.16	(1.10–1.22)
Among bricklayers only	665	443	1.26	(1.08–1.47)	1.22	(1.04–1.44)	–1
Lung cancer morphology
Squamous cell carcinoma	309		1.68	(1.42–1.98)	1.45	(1.22–1.72)	1.53	(1.29–1.81)
Small cell carcinoma	140		1.78	(1.44–2.20)	1.56	(1.26–1.94)	1.61	(1.30–2.00)
Adenocarcinoma	150		1.17	(0.95–1.43)	1.11	(0.91–1.37)	1.12	(0.91–1.37)
Test of homogeneity (p-value)			0.0007		0.017		0.005

Lists A/B, occupations known (list A) or suspected (list B) to be associated with lung cancer; CI, confidence interval; OR1, odds ratio adjusted for study center, age, smoking, and list A/B occupations; OR2, odds ratio adjusted for study center, age, smoking, lists A/B occupations, and education; OR3, odds ratio adjusted for study center, age, smoking, and lists A/B occupations, with blue collar workers as reference.

¹Same as OR1 analysis.