Table 2.

Ischemia-based entry criteria for the ISCHEMIA trial

Test Modality	Diagnostic criterion1
Nuclear perfusion via SPECT or PET	≥10% myocardium ischemic
Echo	≥3/16 segments with stress-induced severe hypokinesis or akinesis
CMR	perfusion: ≥12% myocardium ischemic and/or wall motion: ≥3/16 segments with stress-induced severe hypokinesis or akinesis
Exercise Test without Imaging (Criteria 1–4 must all be met)	Clinical history of typical angina or typical angina during the exercise test Absence of resting ST segment depression ≥1.0 mm or confounders that render exercise ECG non-interpretable (LBBB, LVH with repolarization, pacemaker, etc.) As compared to the baseline tracing, exercise-induced horizontal or downsloping ST segment depression ≥1.5 mm in 2 leads or ≥2.0 mm in any lead; ST segment elevation ≥1 mm in a non-infarct territory. Both the J-point and the ST segment at 80 msec. need to meet criteria. When the HR is >130/min, the ST segment at 60 msec. may be used if the segment at 80 msec. cannot be determined. Either of the following: Workload at which ST segment criteria are met is not to exceed completion of stage 2 of a standard Bruce protocol or 7 METS if a non-Bruce protocol is used or ST segment criteria are met at <75% of the maximum predicted HR

SPECT=single photon emission computed tomography, PET=positron emission tomography; Echo= echocardiography; CMR=cardiac magnetic resonance

¹Additional criteria must be met for confirmation of obstructive coronary artery disease, depending on eGFR and type of ischemia test.