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. 2015 Jun 23;10(6):e0124214. doi: 10.1371/journal.pone.0124214

Table 2. National Health and Medical Research Council Hierarchy of Evidence [27].

Level Definition
I A systematic review of level II studies.
II A randomised controlled trial.
III-1 A pseudorandomised controlled trial (alternate allocation or some other method).
III-2 A comparative study with concurrent controls (non-randomised experimental trial, cohort study, case-control study or interrupted time series with a control group).
III-3 A comparative study without concurrent controls (historical control study, two or more single arm study or interrupted time series without a parallel control group).
IV Case series with either post-test or pre-test/post-test outcomes.