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A-B) Obese Bbs2, Bbs4 and Bbs6 null mice are hyperglycemic (A), and hyperinsulinemic (B). Bbs2, Bbs4 and Bbs6 null mice exhibit glucose intolerance (C-D) and insulin resistance (E-F) relative to wild-type littermate controls. *P<0.05 vs. WT; data expressed as means ± SEM.
