Fig 8. Cinnamon treatment reduces the burden of amyloid beta from the hippocampus of Tg 5XFAD mice.
Tg mice (6 months old) were treated with cinnamon (100 mg/kg body wt/d) and NaB (50 mg/kg body wt/d) orally. After 2 months of treatment, hippocampal sections were immunolabeled with 82E1 antibody (A). Hippocampal homogenates were also analyzed for protein levels of Aβ by Western blot using 6E10 antibody (B, cinnamon; C, NaB). Bands were scanned and results presented as relative to non-Tg control (D, cinnamon; E, NaB). Results represent mean ± SEM of six mice per group. a p < 0.001 vs non-Tg; b p < 0.01 vs Tg. ELISA quantification of Aβ1–42 was performed in hippocampal homogenates (F, TBS soluble fraction; G, detergent soluble fraction). Results represent mean ± SEM of three mice per group. a p < 0.001 vs non-Tg; b p < 0.05 vs Tg; c p < 0.01 vs Tg.