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(A) Schematic of nanobubbles and functionality of Pluronic in changing lipid packing and increasing membrane flexibility; (B) B-mode images of tumors after nanobubble and control microbubble administration; (C) Histological analysis demonstrating DiI label (yellow color) Pluronic nanobubble extravasation into 4T1 breast cancer tumors compared to DiI labeled microbubbles. CD31 on the vasculature was stained green with FITC antibodies. (Unpublished data).
