Table 3.
Intravenous ID 50 determinations of p66 site‐directed mutants
| Bacterial strain | Doses (number of motile bacteria per mousea) | Weeks post‐inoculation | ID50 value |
|---|---|---|---|
| B31‐A3 (wild type) | 103–107 | 2 | 4.64 × 104 |
| 4 | 2.31 × 104 | ||
| Δp66 C3–14 | 103–107 | 2 | >107 |
| 4 | >107 | ||
| C3–14cc clone 23 | 103–107 | 2 | 2.15 × 105 |
| 4 | 5.62 × 105 | ||
| BD205A,D207A clone 2–30 | 103–107 | 4 | 2.15 × 105 |
| BD205A,D207A clone 3–32 | 103–107 | 4 | 4.64 × 104 |
| BDel202–208 clone 3 | 103–107 | 4 | 5.62 × 105 |
| BDel202–208 clone 29 | 103–107 | 2 | >107 |
| 4 | 1 × 106 |
a
Five mice were inoculated per dose per bacterial strain.