Table 1. Demographic and clinical characteristics stratified by HIV and HCV infection status*.
| Parameter | HIV monoinfection (n = 164) |
HCV monoinfection (n = 10) |
HIV/HCV coinfection (n = 73) |
Controls (n = 59) |
p-value** |
|---|---|---|---|---|---|
| Demographic Factors | |||||
|
| |||||
| Age (years) | 46 (40, 52) | 55 (48, 58) | 53 (50, 57) | 42 (35, 49) | <0.0001 |
| Race | 0.27 | ||||
| Caucasian | 21% | 10% | 10% | 14% | |
| African-American | 61% | 90% | 77% | 66% | |
| Latino | 12 % | 0% | 11% | 12% | |
| Other | 6% | 0% | 3% | 9% | |
| Menopause | 37% | 70% | 77% | 31% | <0.0001 |
|
| |||||
| Behavioral factors | |||||
|
| |||||
| Current smoker | 35% | 80% | 67% | 48% | <0.0001 |
| Heavy alcohol use | 6% | 40% | 7% | 7% | 0.01 |
| Marijuana user | 23% | 60% | 30% | 31% | 0.06 |
|
| |||||
| Metabolic factors | |||||
|
| |||||
| BMI (kg/m2) | 25 (22, 29) | 26 (23, 30) | 26 (23, 29) | 27 (23, 29) | 0.43 |
| Waist circumference (cm) | 87 (79, 96) | 89 (82, 101) | 92 (81, 101) | 86 (81, 97) | 0.23 |
|
| |||||
| Lipid Profiles | |||||
|
| |||||
| Apo B (mg/dL) | 58 (46, 77) | 45 (38, 54) | 49 (41, 62) | 59 (46, 80) | 0.01 |
| LDL (mg/dL) | 99 (81, 122) | 73 (57, 97) | 79 (59, 105) | 97 (81, 129) | <0.0001 |
| HDL (mg/dL) | 56 (44, 68) | 64 (48, 85) | 53 (40, 70) | 62 (47, 78) | 0.19 |
| Total Cholesterol (mg/dL) | 178 (157, 204) | 167 (127, 183) | 160 (132, 184) | 182 (169, 209) | 0.0002 |
| Triglycerides (mg/dL) | 96 (70, 136) | 77 (72, 95) | 97 (83, 132) | 74 (51, 122) | 0.01 |
|
| |||||
| HCV-related factors | |||||
|
| |||||
| HCV-RNA (× 1000 IU/ml) | - | 799 (698, 7460) | 2315 (834, 3930) | - | <0.0001 |
| Liver Stiffness (kPa) | 4.3 (3.6, 5.4) | 6.0 (4.2, 9.7) | 7.1 (5.3, 10.4) | 4.4 (3.7, 5.3) | <0.0001 |
|
| |||||
| HIV-related factors | |||||
|
| |||||
| HIV-RNA (copies/ml) | 35 (20, 453) | - | 66 (20, 470) | - | 0.48 |
| CD4 cells/mm3) | 574 (360, 747) | - | 517 (326, 746) | - | <0.0001 |
| CD4 nadir (cells/mm3) | 228 (123, 331) | - | 185 (94, 293) | - | <0.0001 |
| History of AIDS | 33% | - | 49% | - | <0.0001 |
| HAART use | 84% | - | 81% | - | <0.0001 |
*
Data are presented as medians (IQR) or percentages
**
p-values are based on Wilcoxon rank sum test, chi-square test or Fisher's exact test.