Flow diagram of patients included in the primary analysis.
Abbreviations: GCS, Glasgow Coma Scale; GOSE, Glasgow Outcome Scale – Extended; HR, heart rate; SBP, systolic blood pressure; TBI, traumatic brain injury.
*Both cohorts include 4 patients where there was insufficient data to determine a specific cohort. For all 4, the study kit had been opened, but no fluid was infused.
†No qualifying vital signs recorded or no traumatic mechanism. The qualifying SBP must have been ≤ 70 or 71-90 accompanied by a heart rate ≥ 108 beats per minute.
‡No GCS ≤ 8 recorded prior to enrollment or met shock cohort criteria after shock enrollment was closed.
§Two regional sites had fewer than 4 eligible patients in each of the cohorts. Patients enrolled from these sites were excluded from this analysis.