Table 2.

Comparisons of sCCL22 Levels in Glioma Cases and Controls, UCSF Adult Glioma Study, 1997–2012

			Cases		Controls
Value	Category		n	Mean ± SEM	n	Mean ± SEM	t-test p-value**
sCCL22 ng/mL	All		1208	1.23 ± 0.03	976	1.60 ± 0.03	<0.0001
Value	Category	Value (Quartile for Controls)	n	%	n	%	OR* (95% CI)	OR p-value	Trend Test
sCCL22 ng/mL Values	All	0.03–1.05 (Q1)	607	50.2%	245	25%	1.00
		1.05–1.40 (Q2)	247	20.4%	244	25%	0.28 (0.25–0.31)	<0.0001
		1.40–1.87 (Q3)	187	15.5%	243	25%	0.24 (0.19–0.29)	<0.0001
		1.87–15.13 (Q4)	167	13.8%	244	25%	0.21 (0.14–0.30)	<0.0001	P<0.0001
	GBM	0.03–1.05 (Q1)	404	59.3%	245	25%	1.00
		1.05–1.40 (Q2)	116	17.0%	244	25%	0.23 (0.19–0.27)	<0.0001
		1.40–1.87 (Q3)	87	12.8%	243	25%	0.18 (0.14–0.24)	<0.0001
		1.87–15.13 (Q4)	74	10.9%	244	25%	0.16 (0.10–0.24)	<0.0001	P<0.0001
	Non-GBM	0.03–1.05 (Q1)	203	38.5%	245	25%	1.00
		1.05–1.40 (Q2)	131	24.9%	244	25%	0.38 (0.33–0.43)	<0.0001
		1.40–1.87 (Q3)	100	19.0%	243	25%	0.34 (0.27–0.41)	<0.0001
		1.87–15.13 (Q4)	93	17.6%	244	25%	0.30 (0.20–0.41)	0.0009	P<0.0001
Log CCL22	All	NA (continuous log CCL22)	1208	NA	976	NA	0.24 (0.17–0.33)	<0.0001	NA

^*Cluster analysis was performed to control for variation within each batch. Models were adjusted for batch number, age (continuous), race (white/non-white), gender, education (college vs no college), and smoking (ever vs never).

^**T-test comparing sCCL22 means between cases and controls.

SE=Standard error