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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Stem Cells. 2015 May 25;33(7):2320–2330. doi: 10.1002/stem.2048

Figure 5. Aberrant cell cycle pattern of HSPCs in Faap20−/− mice after chronic MMC stress.

Figure 5

Faap20−/− mice and their WT littermates at 6-8 weeks of age were injected with 0.8mg/kg MMC weekly. The mice were sacrificed and analyzed after 8 weeks of IP administration. (A) WBC, RBC,PLT counts and the Hb level in Faap20−/− were significantly decreased compared to WT mice after 8 weeks of MMC treatment. (B) Decreased number of LKs and MPPs subpopulation in Faap20−/− mice after MMC stress. (C) The CMPs and MEPs, but not GMPs population show aberrant cell cycle pattern in MMC-treated Faap20−/− mice. The representative FACS graphs are shown on right. (D) The number of SLAM cells was progressively declined during long-term MMC stress in Faap20−/− mice. (E) Increased cycling (S/G2M) cells in the SLAM population of Faap20−/− mice after 8 weeks of MMC injection. The representative FACS graphs are shown on right.