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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Liver Int. 2015 Jan 22;35(7):1886–1892. doi: 10.1111/liv.12780

Table 1.

Demographic, clinical, and treatment characteristics of the cohort, by the degree of hepatic fibrosis based on the AST-to-platelet ratio index

APRI <1.5
No significant fibrosis (n=19,281)
APRI ≥1.5
Significant fibrosis (n=1,027)
P
Age, years 34 (29–40) 34 (30–39) <0.001
Male sex 7,771 (40) 621 (59) <0.001
WHO clinical stage
 1 or 2 6,734 (35) 180 (18) <0.001
 3 or 4 12,441 (65) 846 (82)
Body mass index
 >25 1,679 (9) 40 (4) <0.001
 18–25 11,868 (63) 551 (56)
 <18 5,201 (28) 402 (40)
Tuberculosis 2,899 (15) 238 (23) <0.001
CD4+ count, cells/mm3
 >200 6,326 (34) 146 (15)
 100–200 6,024 (33) 260 (27) <0.001
 <100 6,089 (33) 568 (58)
ART regimen
 NRTI
  D4T+3TC 6,962 (36) 447 (44) <0.001
  AZT+3TC 5,702 (30) 214 (21)
  TDF+XTC 6,490 (34) 360 (35)
 NNRTI
  NVP 13,528 (70) 554 (54) <0.001
  EFV 5,753 (30) 473 (46)

All values are median (IQR) or number (%).

Abbreviations: APRI, AST-to-platelet ratio index; AST, aspartate aminotransferase; WHO, World Health Organization; NRTI, nucleotide reverse transcriptase inhibitor; NNRTI, non-nucleotide reverse transcriptase inhibitor; D4T, stavudine; 3TC, lamivudine; XTC, either lamivudine or emtricitabine; AZT, zidovudine; TDF, tenofovir; NVP, nevirapine; EFV, efavirenz; ART, antiretroviral therapy