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. 2015 Jun 4;33(7):2306–2319. doi: 10.1002/stem.2042

Figure 1.

Figure 1

Neural stem/progenitor cells (NSPCs) in adult mouse subventricular zone (SVZ) express enzymes required for fatty acid oxidation. Cells expressing medium chain acyl CoA dehydrogenase (MCAD [A–E]) and trifunctional protein (TFP [F–J]) are observed in the SVZ (A, F) and hippocampal dentate gyrus (DG) (B, G). A majority of cells expressing these enzymes in SVZ are observed to be colabeled with SOX2, while none of the cells expressing fatty acid oxidation enzymes in DG are labeled with SOX2 (C, H). Higher‐magnification images of MCAD+ cells (D–E) and TFP+ cells (I–J) in SVZ (D, I) and DG (E, J) are shown. In SVZ, fewer than 5% of MCAD+ cells colabel with KI67 and fewer than 5% of KI67+ cells colabel with MCAD. Most MCAD+ cells (in red) do not colabel with glial fibrillary acidic protein (GFAP+) astrocytes (K–O), S100B+ ependymal cells (P–T), or doublecortin (DCX+) neuroblasts (U–Y). All tissues were stained with the pan‐nuclear marker Hoechst (in blue) to demonstrate total cell number. Scale bar = 20 μm. Abbreviations: DCX, doublecortin; DG, dentate gyrus; GFAP, glial fibrillary acidic protein; MCAD, medium chain acyl CoA dehydrogenase; SVZ, subventricular zone; TFP, trifunctional protein.