Figure 3.

TDP-43 and granulins 2 and 3 synergistically delay development, impair growth, and increase bacterial packing. A, Granulin 2 and 3 delay development when coexpressed with TDP-43 (n = 50 per strain). B, Representative micrographs from each strain at L4 stage show that animals reach similar size. C–E, Measurement of animal size at Day 5 of adulthood. Representative images of a wild-type (C) and TDP-43;gran3 (D) worms. Animals <2 SD below the wild-type mean are score scored as small size. Results are shown in E (n = 12). F–H, Representative images of a normal pharynx from a wild-type animal (F) and abnormal bacterial packing in a TDP-43;gran3 animal (G) are shown. Scores for bacterial packing in each strain tested are shown in H (n = 12).