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. 2015 Jun 24;35(25):9315–9328. doi: 10.1523/JNEUROSCI.4808-14.2015

Figure 4.

Figure 4.

Animals expressing TDP-43 with granulin 2 or 3 exhibit circuit-specific neuronal dysfunction. A, Granulin 2 and 3 impair motor coordination when coexpressed with TDP-43. Data are averages from 3 separate trials (n = 12 per trial). TDP-43 with coinjection marker alone was tested and had no effect on thrashing compared with TDP-43 alone (data not shown). B, Coexpression of full-length progranulin (Ppgrrn-1::pgrn-1::rfp) with TDP-43 in a pgrn-1(-) background does not alter motor function (n = 12 per trial). C, Endogenous progranulin does not ameliorate motor defects caused by coexpression of granulins 2 and 3 with TDP-43 (n = 12 per trial). D, Granulins did not impair defecation in TDP-43 animals (n = 15 per trial). E, Granulins did not impair pharyngeal function in TDP-43 animals (n = 15 per trial). F, Pharyngal pumping was measured at Day 5 of adulthood as previously described. No significant differences were seen between strains. Data shown represents one trial (n = 6 per trial). For all panels: ns, not significant; wt or w, wild-type; mut or m, mutant; ***p < 0.0001 by one-way ANOVA. Error bars represent SD. Unless otherwise indicated, data are from Day 1 adult animals.