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Coexpression of TDP-43 and specific granulins reduces lifespan and alters reproductive efficiency. A, Strains expressing both TDP-43 and granulin 3 had a median lifespan of 8 d, compared with 16 d for wild-type (n = 90). Shown is trial 1 of two independent trials (Table 5). B, Percentage of animals with internally hatched progeny for each strain.
