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. 2015 Jun 24;35(25):9315–9328. doi: 10.1523/JNEUROSCI.4808-14.2015

Table 2.

Loss of progranulin does not shorten lifespan in TDP-43 animals

Strain Trial Mean lifespan ± SEM Events/obs Percentage difference from N2 p value summary vs N2 p value summary vs pgrn-1
N2 1 13.8 ± 0.8 77/90
pgrn-1(-) 14.4 ± 0.7 83/90 4.3 ns
N2;TDP-43 11.3 ± 0.7 79/90 −18.1 ns ns
pgrn-1(-);TDP-43 15.7 ± 0.7 77/90 13.8 ns ns
N2 2 16.2 ± 0.5 71/90
pgrn-1(tm985) 14.4 ± 0.5 67/90 −11.2 *
N2;TDP-43 14.9 ± 0.6 80/90 −7.8 ns ns
pgrn-1(-);TDP-43 16.1 ± 0.7 56/90 −0.9 ns *
N2 3 14.7 ± 0.7 54/80
pgrn-1(-) 14.2 ± 0.7 50/80 −3.4 ns
N2;TDP-43 11.6 ± 0.6 60/80 −21.0 ns ns
pgrn-1(-);TDP-43 13.2 ± 0.8 40/80 −10.2 ns ns

Three independent lifespan trials were performed comparing wild-type and pgrn-1(-) strains with and without TDP-43. Average lifespans of strains were compared using the Mantel–Cox statistical test (ns, not significant;

*p < 0.01).