Table 5.

Lifespan of TDP-43;gran3 animals

Strain	Trial	Mean lifespan ± SEM	Events/obs	Percentage difference compared with N2	p value summary vs N2	p value summary vs pgrn-1(-)
N2	1	15.1 ± 0.7	68/90	—	—	—
pgrn-1(tm985)		15.0 ± 0.6	77/90	−0.7	ns	—
pgrn-1(-);TDP-43		12.6 ± 0.7	68/90	−16.6	ns	ns
pgrn-1(-);gran3		15.9 ± 0.9	57/90	5.3	ns	ns
pgrn-1(-);TDP-43;gran3		8.1 ± 0.4	71/90	−46.4	***	***
N2	2	16.4 ± 0.8	72/90	—	—	—
pgrn-1(-)		15.0 ± 0.8	60/90	−8.5	ns	—
pgrn-1(-);TDP-43		13.3 ± 0.7	73/90	−18.9	**	ns
pgrn-1(-);gran3		17.4 ± 1.0	39/90	6.1	ns	ns
pgrn-1(-);TDP-43;gran3		8.9 ± 0.5	74/90	−45.7	***	***

Two independent lifespan trials were performed on strains as indicated. Average lifespans of strains were compared using the Mantel–Cox statistical test (ns, not significant;

**p < 0.01,

***p < 0.0001).