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. 2015 Jun 24;35(25):9491–9507. doi: 10.1523/JNEUROSCI.4404-14.2015

Figure 6.

Figure 6.

Sensory neuron-specific ERK1/2 double knock-out mice exhibit altered baseline sensitivity to noxious stimuli. A, B, Paw withdrawal latency (in seconds) to a radiant heat source directed at either the hindpaw (A) or tail (B) was measured in female ERK dKO mice compared with control and single knock-out littermates (n = 5–8/genotype; one-way ANOVAs). **p < 0.01. C, Paw withdrawal threshold to an innocuous, calibrated von Frey mechanical stimulus was measured in female ERK dKO mice and compared with control and single knock-out littermates (n = 5–8/genotype, one-way ANOVA). D, Randall-Selitto tail pinch assay was used to measure tail withdrawal thresholds in female ERK dKO mice compared with control and single knock-out littermates (n = 5–8/genotype). ***p < 0.001 (one-way ANOVA). E, Data from Randall-Selitto assay in D were separated into distal (1 mm from tail end), medial (2 mm from tail end), and proximal (3 mm from tail end) bins (n = 5–8/genotype). ***p < 0.001 (two-way RM ANOVA with Bonferroni post test).