Table 1.
Colorectal Cancer Patient and Tumor Characteristics (N = 431)
| Primary Tumor Location* | ||||
|---|---|---|---|---|
| Distal Colon | Proximal Colon | Rectum | ||
| Characteristic | (N=170) No. (%) |
(N=171) No. (%) |
(N=90) No. (%) |
P-value† |
| Age in Years median (range) | 59 (27–92) | 66 (29–89) | 59 (31–85) | <0.001 |
| Gender | 0.09 | |||
| Men | 97 (57%) | 92 (54%) | 61 (68%) | |
| Women | 73 (43%) | 79 (46%) | 29 (32%) | |
| Tumor Grade | 0.04 | |||
| Well Differentiated | 7 (4%) | 10 (6%) | 8 (9%) | |
| Moderately Differentiated | 106 (62%) | 88 (51%) | 52 (58%) | |
| Poorly Differentiated | 31 (18%) | 48 (28%) | 14 (16%) | |
| Unknown | 26 (15%) | 25 (15%) | 16 (18%) | |
| KRAS Mutation Status | 0.51 | |||
| Mutant | 69 (41%) | 78 (46%) | 33 (37%) | |
| Wildtype | 91 (54%) | 83 (49%) | 46 (51%) | |
| Unknown | 10 (6%) | 10 (6%) | 11 (12%) | |
| KRAS Mutation | 0.012 | |||
| Gly12Ala | 8 (12%) | 1 (1%) | 2 (6%) | |
| Gly12Asp | 20 (29%) | 31 (40%) | 9 (27%) | |
| Gly12Arg | 2 (3%) | 0 (0%) | 1 (3%) | |
| Gly12Cys | 9 (13%) | 5 (6%) | 3 (9%) | |
| Gly12Ser | 6 (9%) | 5 (6%) | 3 (9%) | |
| Gly12Val | 20 (29%) | 15 (19%) | 5 (15%) | |
| Gly13Asp | 4 (6%) | 21 (27%) | 10 (30%) | |
| BRAF Mutation Status | <0.001 | |||
| Mutant | 9 (5%) | 24 (14%) | 2 (2%) | |
| Wildtype | 147 (86%) | 133 (78%) | 81 (90%) | |
| Unknown | 14 (8%) | 14 (8%) | 7 (8%) | |
*
Proximal and distal colon tumors were demarcated by the splenic flexure. Rectal tumors were defined as those within 15 cm of the anal verge.
†
P value was based on Kruskal-Wallis Test for age and χ2 test for other characteristics. Patients with unknown characteristics were excluded.