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. 2015 Jul;22(7):336–343. doi: 10.1101/lm.038083.115

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© 2015 Venna et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 2. — Neuroprotection was seen with delayed treatment with a GSK-3β inhibitor. Infarct size assessment and NORT were performed 7 d after MCAO. (A) Representative TTC stained coronal sections showing neuroprotective effects of delayed GSK-3β inhibitor treatment (initiated 2 h after stroke onset) compared with vehicle group (n = 10/group); (B) Quantification confirms the significant neuroprotective effect with GSK-3β inhibitor VIII compared with vehicle in cortex, striatum, and total hemisphere after stroke; (C) GSK-3β inhibition also significantly improved the percentage time spent with a novel object after stroke ((*) P < 0.05) (n = 10 per group). (D) GSK-3β inhibitor VIII treated mice had significantly improved learning recovery on rotarod compared with vehicle-treated mice (amount of time spent on accelerating rod after stroke). (*) P < 0.05.