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. 2015 Jun 24;6:140. doi: 10.3389/fneur.2015.00140

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Copyright © 2015 Sherman, Fuller, Marcus, Yu, Zhang, Chamberlin, Saper and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Motor effects of MLR stimulation. (A) Acute injection of 3 nl glutamate agonist (10%) ibotenic acid in the MLR region unilaterally induces contra-lateral rotation and c-Fos expression (black) in the MLR region, but not in PPT cholinergic neurons (brown, at lower left edge of circumscribed area) (B). The same stimulation induces Fos in spinal motor neurons (C). Fos is seen in spinal cord motor neurons ipsilateral to the stimulation site (D). Lesions of the VMM (E) block neither circling behavior nor Fos expression in the motor ChAT-ir neurons induced by unilateral MLR stimulation.