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. 2015 Jun 23;22(7):789–797. doi: 10.1128/CVI.00191-15

FIG 6.

FIG 6

Representative microscopic changes in the livers and spleens of C57BL/6 mice not immunized or immunized with encapsulated Brucella ovis ΔabcBA and challenged with wild-type B. ovis (all micrographs are from challenged mice). (A and B) Numerous microgranulomas associated with necrosis in the liver of a nonimmunized C57BL/6 mouse (A), compared to only scarce microgranulomas (black arrows) in the liver of a C57BL/6 mouse immunized with encapsulated B. ovis ΔabcBA (B). Hematoxylin and eosin staining. Bars = 100 μm. (C and D) Microgranulomas (black arrow) in the spleen of a nonimmunized C57BL/6 mouse (C) and rare neutrophils in the spleen of a C57BL/6 mouse immunized with encapsulated B. ovis ΔabcBA (D). Hematoxylin and eosin staining. Bars = 50 μm.